Buccal mucoadhesive tablets are dry placing in contact with buccal mucosa. Aug 06, 2012 formulation and evaluation of mucoadhesive buccal patches of labetalol. Overview and future potential of buccal mucoadhesive films. Buccal mucoadhesive tablets are dry dosage forms that have to be moistened prior. Research paper formulation and evaluation of pimozide. Overview and future potential of buccal mucoadhesive films as. Formulation and evaluation of mucoadhesive buccal patches. The use of mucoadhesive polymers in buccal drug delivery has a greater. Overview on buccal drug delivery systems pharmainfo.
Preparation and evaluation of buccal patches of clotrimazole for oral candida infections. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moisture. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. These are useful for the systemic delivery of drug as well as for local targeting of drug to a particular region of the body. Index terms fluxotine hcl, buccal patches, invitro release, evaluation i.
The main route of administration for drug products is the oral route, yet biologics are initially developed as injectables due to their limited stability through the gastrointestinal tract and solubility issues. They may be supplied as mucoadhesive buccal tablets or as other mucoadhesive solid or semisolid preparations. The patch may contain a mucoadhesive polymer layer which bonds to the oral mucosa, gingiva, or. Due to the versatility of the manufacturing processes, the release can be oriented either towards. For example, compacts have been used for drug delivery to the oral cavity, 51 and powders and nanoparticles have been used to facilitate drug administration to the nasal mucosa. The mucoadhesive buccal patches were prepared by solvent casting technique using two different mucoadhesive polymers. A piece of porcine buccal mucosa was tied to the open mouth of a glass vial filled completely with isotonic phosphate buffer, ph 6. Buccal mucoadhesive tablets buccal mucoadhesive tablets are dry dosage forms that have to be moistened prior to. The novel type buccal dosage forms include buccal adhesive tablets, patches, films, semisolids ointments and gels and powders. Buccal mucoadhesive patchesgels buccal mucoadhesive tablets of lercanidipine. Pdf buccal tablet as a promising mucoadhesive drug delivery. Design of buccal mucoadhesive patches the different components of buccal mucoadhesive patches are as following. Novel buccal dosage forms the novel type buccal dosage forms include buccal adhesive tablets, patches, films, semisolids ointments and gels and powders.
A hydratable mucoadhesive base layer, a nonadhesive reservoir layer and a waterimpermeable carrier film sandwiched between and bonded to the base layer and the reservoir layer are the elements which form the trilaminate film. The backing membrane was prepared by using sodium alginate. Apr 10, 20 give a brief account of mucoadhesive polymers for buccal delivery. Formulation and evaluation of buccal patches for delivery of. They can be prepared by two methods solvent casting method direct milling method 32020 31 department of pharmaceutical technology, lj institute of pharmacy, ahmedabad. They are generally hydrophilic as they contain many hydrogen macromolecules due to the large amount of water approximately 95% within its composition. View and download powerpoint presentations on buccal cavity ppt. Permeation of ond was calculated ex vivo using porcine buccal membrane. Can toll free call 18005268630 for gmt office hours. Films can circumvent the difficulty of the relatively short. In addition to this, studies have been conducted on the development of. Mucoadhesive polymers these are the main component for adhesion. Buccal patches films they are long, flat, thin thickness, transparent with high surface area.
Patel nagar, dehradun, uttarakhand248001, india the objective of this study was to develop mucoadhesive buccal tablets of simvastatin using mucoadhesive polymers. Give a brief account of mucoadhesive polymers for buccal delivery. D browns college of pharmacy 2 department of pharmaceutics, m. Formulation, development and invitro evaluation of. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Though the buccal mucosa is less permeable than sublingual mucosa, it is better suited to the use of retentive systems such as mucoadhesive patches or tablets, because mucosa has a smooth and relatively immobile surface for placement of such systems. Have a look at this presentation and find out more about it. Oct 14, 2012 buccal drug delivery and mucoadhesivitymucoadhesion of the device is a key elementthe term mucoadhesive is commonly used for materials that bind to the mucin layer of a biological membraneachieve systemic delivery of drugs include tablets, patches, tapes, films, semisolids and powders. The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moisture absorption as well as for in vitro and in vivo bioadhesion. Buccal patchesfilms they are long, flat, thin thickness, transparent with high. Mucoadhesion involves several types of bonding mechanisms, and it is the interaction between each process that allows for the adhesive process.
Formulation and evaluation of mucoadhesive buccal patches of labetalol. Apr 15, 2016 the main route of administration for drug products is the oral route, yet biologics are initially developed as injectables due to their limited stability through the gastrointestinal tract and solubility issues. Literature studies on preparation and evaluation of buccal. Design and characterization of mucoadhesive buccal patches of diclofenac sodium. Development of mucoadhesive patches for buccal administration of carvedilol. A free powerpoint ppt presentation displayed as a flash slide show on id. Buccal patches were left to swell for 1 hour on the surface of 2% agar plate, it was allowed to stand until it is solidified to form a gel at room temperature. Formulation and invitro evaluation of mucoadhesive buccal. Sathish and shayeda abstract patches of cyproheptadine hydrochloride cph which is a sedating antihistamine with antimuscarinic, serotoninantagonist, and calciumchannel blocking action.
Formulation and evaluation of buccal patches for delivery. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Research paper formulation and evaluation of pimozide buccal. Mucoadhesive drug delivery systems in the past have been formulated as powders, compacts, sprays, semisolids, or films. Introduction ecent years have seen an increasing interest in the development of novel mucoadhesive buccal dosage forms. Mucoadhesive patch were weighed individually x 0 and placed separately in 2% agar gel plates and incubated at 370c10c. Nurse powerpoint template is a free registered nurse powerpoint template there is now an effective treatment for people suffering from keratosis pilaris skin conditions. Mucoadhesive buccal tablets are prepared by compression of mono or multi.
Buccal mucoadhesive tablets are dry dosage forms that have to be moistened prior to placing in contact with buccal mucosa. Jagadeesh singh the mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic circulation and avoiding the first pass metabolism. Patches films liquid buccal adhesive dosage form viscous liquids mucoadhesive buccal films various mucoadhesive devices has been formulated like tablets,27 patches, 28 devices, strips,29 ointments,30 gels, 31 26 disks. Department of pharmaceutical technology,41020 lj institute of pharmacy, ahmedabad 66 67. In addition to this, studies have been conducted on the development of controlled or slow release delivery systems for systemic and local therapy of diseases in the oral cavity. Mucoadhesive drug delivery systems pubmed central pmc.
Formulation and evaluation of buccal patches of diclofenac sodium shubhra pandey abstract. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Mucoadhesive preparations contain one or more active substances intended for systemic absorption through the buccal mucosa over a prolonged period of time. The important drug properties that affect its diffusion through the patch as well as the buccal include molecular weight, chemical functionality and melting point. Find powerpoint presentations and slides using the power of, find free presentations research about buccal cavity ppt. An approach to prepare buccal patches using chitosan and hpmc polymers jose, jobin, charyulu, r. The surface ph was measured by means of ph paper placed on the surface of the swollen patch. A piece of porcine buccal mucosa was glued on a support and kept in a vessel placed in a thermostatic bath at 37 c 0. Many mucoadhesive buccal films have been formulated to release drugs locally in order to treat for fungal infections in the oral cavity, such as oral candidiasis donnelly et al. For mucoadhesive measurements, films were cut in portions of 4 cm 2 and pasted on a support, connected to the dynamometer lehrmittelban, professor dr. The mucoadhesive buccal film of lisinopril were prepared by using various polymers like hpmc k4m, sodium cmc, pvp k30, eudragit rl 100, carbopol 934 by solvent casting method and evaluated for physical appearance, thickness, weight uniformity, folding endurance,percentage swelling index, percentage moisture content, drug diffusion studies and drug content estimation. Chitosan was used as bioadhesive polymer and different ratios of chitosan to pvp k. Preparation of mucoadhesive buccal patches buccoadhesive patches containing varying amounts of chitosan and pectin were prepared by solvent casting method as reported by kaur et al.
Mucoadhesion describes the attractive forces between a biological material and mucus or mucous membrane. Semalty a, bhojwani m, bhatt gk, gupta gd, shrivastav ak. Patches with any imperfections, entrapped air, or differing in thickness, weight or content uniformity were excluded from further studies. Buccal patchesfilms they are long, flat, thin thickness, transparent with high surface area. Its stereotyped clinical presentation allows ready diagnosis, but the possible. Formulation and evaluation of mucoadhesive buccal film of. Presentations ppt, key, pdf logging in or signing up. Mucoadhesive buccal patches containing propranolol hydrochloride were prepared using the solvent casting method. Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and.
Formulation and evaluation of a bioadhesive patch for buccal. Stability of buccal tablets surface ph study in vitro drug release studies ex vivo mucoadhesion time in vivo mucoadhesive performance 10. Development of mucoadhesive patches for buccal administration. Formulation and evaluation of buccal patches of simvastatin. Formulation and evaluation of mucoadhesive buccal patch of. The drug containing layer was prepared by using pectin. Formulations of buccal dosage forms include adhesive tablets3, 4, gels5, 6 and patches7, 8, of which patches are preferable in terms of flexibility and comfort 9.
Buccal mucoadhesive tablets 12 buccal mucoadhesive patches gels buccal mucoadhesive tablets of lercanidipine. Mucoadhesive strength of all fabricated buccal patches was measured ex vivo n 3 on a modified physical balance using the method described by gupta et al. In order to avoid injections, a myriad of investigations on alternative administration routes that can bypass enzymatic degradation and the firstpass effect are found in the literature. A trilaminate film suitable for prolonged and sustained delivery of an active ingredient in a buccal cavity is disclosed. Preparation of mucoadhesive patches for buccal administration. Preparation of buccal mucoadhesive controlled drug delivery systems of lercanidipine hydrochloride using various mucoadhesive and rate controlling polymers either alone or in combination. Advantages of mucoadhesive buccal drug delivery systems 1. Preparation and evaluation of mucoadhesive buccal films of clotrimazole for oral candida infections.
Formulation and evaluation of buccal patches of simvastatin by using different polymers shalini mishra1, g. These attributes make the buccal mucosa more suitable for sustained delivery applications. Formulation and evaluation of buccal patches of diclofenac sodium. Worlds best powerpoint templates powerpoint ppt presentation.
Buccal drug delivery and mucoadhesivitymucoadhesion of the device is a key elementthe term mucoadhesive is commonly used for materials that bind to the mucin layer of a biological membraneachieve systemic delivery of drugs. Design and evaluation of mucoadhesive buccal films of diltiazem hydrochloride. Tizanidine hydrochloride thcl is a centrally acting. Formulation and evaluation of pimozide buccal mucoadhesive patches 741 evaluation of the patches formulated patches were subjected to the preliminary evaluation tests. Ppt buccal drug delivery system powerpoint presentation. The major categories are wetting theory, adsorption theory, diffusion theory, electrostaticic theory, and fracture theory. Preparation of buccal mucoadhesive controlled drug delivery systems of. Buccal mucoadhesive tablets buccal mucoadhesive tablets are dry dosage forms that have to be moistened prior to placing in contact with buccal mucosa. Discuss the merits and demerits of mucoadhesive buccal drug delivery. He used hpmc e 15 as main polymer for preparation of buccal patch using solvent casting method. Formulation and evaluation of mucoadhesive buccal patches of.
Patchesfilms liquid buccal adhesive dosage form viscous liquids mucoadhesive buccal films various mucoadhesive devices has been formulated like tablets,27 patches, 28 devices, strips,29 ointments,30 gels, 31 26 disks. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. He formulates the optimum patch having 2500 mg of hpmc e15. Jun 09, 2010 mucoadhesive strength of all fabricated buccal patches was measured ex vivo n 3 on a modified physical balance using the method described by gupta et al. In order to avoid injections, a myriad of investigations on alternative administration routes that can bypass enzymatic degradation and the firstpass effect are found in the. A piece of porcine buccal mucosa was tied to the open mouth of a glass vial filled completely with. Bilayerd films were prepared by solvent casting technique using different concentration of two polymers namely, sodium alginate and pectin. Buccal drug delivery system authorstream presentation.
The results indicate that suitable bioadhesive buccal patches with desired. Development of mucoadhesive patches for buccal administration of ibuprofen. Chitosan based mucoadhesive buccal patches containing. An approach to prepare buccal patches using chitosan and hpmc polymers. Formulation and evaluation of a bioadhesive patch for. Ppt buccal mucoadhesive drug delivery powerpoint presentation free to view id.
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